20 Best Songs About Disease

By Nico Gonzalez

It’s not easy to talk about diseases. They can be frightening, uncomfortable, and sometimes even deadly. The truth is that we are all susceptible to illness at one point or another in our lives, it’s just a question of when. And while some people may find it easier than others to cope with the reality that they have a disease, for many of us, it can be incredibly difficult.

But through the power of music, we can often find solace in the words of others who have gone through similar experiences. These songs about disease offer a message of hope, resilience, and even acceptance. They remind us that we are not alone in our struggles and that it is possible to get through even the darkest of times. Here are 20 of the best songs about disease, in no particular order.


In My Blood – Shawn Mendes

Shawn Mendes - In My Blood (Official Music Video)

In My Blood is a gripping song about Shawn Mendes’ personal experience with anxiety and how it affects his daily life. The lyrics are raw and vulnerable, and they perfectly capture the feeling of being trapped by your own mind. The song is a reminder that we are all human and we all struggle sometimes. It’s an anthem for anyone who feels like they’re fighting a battle they don’t know how to win. Some people might find the song depressing, but I think it’s incredibly powerful and cathartic.

So Unfair – Korn

Korn - So Unfair [Lyrics Video]

So Unfair by Korn is a song about the unfairness of life. The lyrics talk about how life can be cruel and unjust, and how it’s not fair that some people have to suffer while others don’t. The song is a reminder that life can be tough and that sometimes we just have to power through it. Its lyrics are about disease, but they can be applied to any difficult situation in life.

Her Diamonds – Rob Thomas

Rob Thomas - Her Diamonds (Official Video)

The song is about a man who is reflecting on his past relationship. He remembers all of the good times they had together, and how she always seemed to bring light into his life. However, the relationship eventually ended due to her addiction to drugs. The song is written in a way that makes it sound like the man is speaking to her from beyond the grave, and he pleads with her to get help before it’s too late.

Myxomatosis – Radiohead

Myxomatosis is a song by Radiohead about a virus that leads to the death of rabbits. It is a metaphor for the fear and paranoia that come with being in a relationship. The lyrics are dark and intense, reflecting the feelings of anxiety and terror that come with being in a relationship. Its lyrics are about a disease that causes death in rabbits, but it can be easily interpreted to be about any deadly virus.

Spasticus Autisticus – Ian Dury

Ian Dury & The Blockheads : Spasticus Autisticus

Released in 1981, “Spasticus Autisticus” is a protest song by Ian Dury about the mistreatment of people with autism. The song is an attack on the British government and its policies toward people with disabilities. Its lyrics are about as explicit as you can get, with Dury singing “I’m spasticus autisticus, I’m a real live jigsaw puzzle and I’m in charge.”

Mystery Disease – MGMT

Mystery Disease is a track about the fear of the unknown. It’s one of MGMT’s most popular songs and is about a disease that people don’t know anything about. The song is dark and eerie, and it really captures the feeling of fear that comes with not knowing what’s wrong with you. Its lyrics are about a person who is scared and doesn’t know what to do about the disease that’s threatening their life.

Won’t Stop Running – A Great Big World

A Great Big World - Won't Stop Running

“Won’t Stop Running” is a great ballad about the dedication and hard work that goes into chasing a dream. The song is relatable to anyone who has ever felt like they’re not good enough or that they have to keep running to catch up to their goals. It’s a beautiful song about the power of perseverance. Its lyrics are about a young man who is running away from his problems and chasing his dreams, but he’s also running towards a disease that could kill him.

Industrial Disease – Dire Straits

Industrial Disease

Dire Straits’ “Industrial Disease” is one of the most chilling songs about disease ever written. The song is about the dangers of working in a factory, and how even the simplest tasks can lead to a deadly illness. The lyrics are haunting, and the music is downright spine-chilling. This is a must-listen for anyone who wants to get a glimpse into the dark side of the disease.

The HIV Song – Ween

The H.I.V. Song (Live)

Ween is a band that is not afraid to experiment with their music. In fact, they are well-known for their eclectic sound. So it’s no surprise that their song about HIV, “The HIV Song,” is just as unique as the rest of their catalog.

The song is a light-hearted look at the virus, and its catchy chorus will have you singing along in no time. While the lyrics might not be the most sensitive, they do offer a unique perspective on a topic that is often considered taboo.

The Vampyre of Time and Memory – Queens of the Stone Age

The Vampyre of Time and Memory

Queens of the Stone Age’s “The Vampyre of Time and Memory” is a haunting ballad about a man struggling with a debilitating disease. The lyrics are poetic and evocative, painting a picture of a life slipping away bit by bit. This song is a must-listen for anyone who has been affected by illness. Its lyrics are about acceptance and coming to terms with the fact that life is finite.

Lithium – Nirvana

Nirvana - Lithium (Official Music Video)

Lithium is a track about a man who is struggling with bipolar disorder. The lyrics are dark and depressing, but they offer an insight into what it’s like to live with bipolar disorder. The song is a reminder that mental illness is a real and serious problem that should not be ignored. Its lyrics are about a man’s struggles with his mental health and the temptation to commit suicide.

Down With Disease – Phish

Down With Disease is one of the most popular songs by Phish, and it’s easy to see why. The song is about a person who is struggling with a disease, and the lyrics are both emotive and powerful. The song is a great example of how music can be used to express emotions and feelings that words sometimes can’t. Its lyrics are about a person who is suffering from a disease and is trying to find hope and meaning in life.

Streets of Philadelphia – Bruce Springsteen

Bruce Springsteen - Streets of Philadelphia (Official Video)

Streets of Philadelphia is a song about the struggles of AIDS and HIV. The songwriter, Bruce Springsteen, was inspired to write it after seeing the movie Philadelphia with Tom Hanks. The song addresses the feelings of isolation and hopelessness that come with the disease. It’s a haunting and powerful ballad that is still relevant today. Its lyrics are about a man who is dying of AIDS and his thoughts on life and death.

Chandelier – Sia

httpv://www.youtube.com/watch?v=2vjPBrBU-™

Sia’s “Chandelier” is a haunting ballad about addiction and self-destruction. The lyrics are dark, but the song is beautiful and moving. It’s one of our favorites on the list. Its lyrics are about a young girl who is struggling with addiction and is on the verge of self-destruction. Its lyrics are about a young girl who is struggling with addiction and is on the verge of self-destruction.

Until It Sleeps – Metallica

Metallica: Until It Sleeps (Official Music Video)

Released on the band’s 1996 album Load, “Until It Sleeps” is one of Metallica’s heaviest songs. The lyrics are about frontman James Hetfield’s struggle with addiction and depression, and the song deals with the idea of suicide. The song was nominated for a Grammy Award for Best Rock Song. Its lyrics are about how addiction can feel like a disease, with lines like “In your face / all the time / like a dog that’s been kicked”.

Anna’s Song – Open Fire

Silverchair - Ana's Song (Open Fire) (Official Video)

Anna’s Song – Open Fire by Coldplay is a haunting ballad about a woman who is dying of cancer. The lyrics are written from the perspective of her loved ones, who are coping with her illness and preparing for her death. It’s a beautiful and emotional song that captures the sadness and hope of cancer patients and their families. Its lyrics are about “gathering around the open fire” of her life as it ends.

Disease – Matchbox 20

Matchbox Twenty - Disease (Official Video)

Matchbox 20 is a band that knows how to write an emotional song. “Disease” is one of their most popular songs, and it’s easy to see why. The lyrics are raw and honest, and they perfectly describe the feeling of being trapped in a relationship that’s bad for you. If you’re struggling with a toxic relationship, this song is for you. Its lyrics are about how disease can spread, just like a relationship can.

Anyone – Demi Lovato

Demi Lovato - Anyone (Official Lyric Video)

Anyone by Demi Lovato is an incredible song about self-acceptance and fighting against the odds. The lyrics are so powerful and Lovato’s voice is so raw and stunning that it’s hard not to be moved by the song. In the song, Lovato sings about how she was always told that she was “anything but normal” and how she struggled with accepting herself for who she was. 

Spreading the Disease – Queensryche

Queensryche - Spreading The Disease

“Spreading the Disease” is a song by the American heavy metal band Queensryche. The song is about the spread of a deadly virus, and its lyrics are based on Richard Preston’s 1994 nonfiction book The Hot Zone. The song was released as the lead single from the band’s 1995 album Operation: Mindcrime II. Its lyrics are about the spread of a deadly virus, and its lyrics are based on Richard Preston’s 1994 nonfiction book The Hot Zone.

Nobody’s Empire – Belle and Sebastian

Belle & Sebastian 'Nobody's Empire'

Nobody’s Empire is a song by Scottish indie pop bands Belle and Sebastian. It was released as the lead single from their ninth studio album, Girls in Peacetime Want to Dance, on 18 January 2015. The song was written by frontman Stuart Murdoch, and produced by Ben Hillier. The song is about the break-up of Murdoch’s long-term relationship and is written in the form of a letter to his ex-partner.